Reaction: ISGylation of PKR
- in pathway: PKR-mediated signaling
PKR (EIF2AK2) is modified by ISG15 ligase complex on lysine residues 69 and 159, which activates PKR by dimerization and autophosphorylation, leading to down-regulation of protein translation without the necessity of RNA binding to PKR (Okomura et al, 2013).
Reaction - small molecule participants:
PPi [cytosol]
AMP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9833973
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
diphosphate(3-)
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-9833973