Reaction: p-PKR dimer phosphorylates DHX9
- in pathway: PKR-mediated signaling
ATP-dependent RNA helicase A (DHX9, RHA, DDX9) unwinds numerous nucleic acid substrates such as dsDNA and dsRNA, facilitating viral replication. Protein kinase R (PKR, EIF2AK2) phosphorylates DHX9, perturbing its association with dsRNA. Modification occurs in the first 263 amino acids of DHX9, where the dsRNA binding motifs are located. Blocking the interaction between PKR and DHX9 increases the infectivity of HIV-1 (Fujii et al, 2001; Sadler et al, 2009).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9836159
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9836159