Reaction: p-PKR dimer phosphorylates ILF3:ILF2
- in pathway: PKR-mediated signaling
Activated PKR phosphorylates interleukin enhancer-binding factor 3 (also known as NF90, NFAR, DRBP76, MBP4, or ILF3) at residues T188 and T315, resulting in dissociation of p-ILF3 from its complex with ILF2, retaining and accumulating p-ILF3 in the cytosol. On viral infection, cytosolic p-ILF3 binds to viral mRNA, inhibiting its translation. Since ILF3 also activates PKR, both processes appear to be part of a feedback loop, enhancing PKR signaling (Ting et al, 1998; Patel et al, 1999; Harashima et al, 2010).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9836383
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9836383