Reaction: p-PKR dimer phosphorylates SNCA
- in pathway: PKR-mediated signaling
Activated protein kinase R (PKR, EIF2AK2) can phosphorylate alpha-synuclein (SNCA) on S129 and other residues. In synucleopathies (Parkinson disease, Lewy body dementias), about 90% of aggregated SNCA found in inclusion bodies are phosphorylated. Inhibition or overexpression of PKR in cells has decreasing or increasing effect, respectively, on cellular degeneration (Reimer et al, 2018; Reimer et al, 2022).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9836435
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9836435