Reaction: p-PKR dimer phosphorylates SPHK1
- in pathway: PKR-mediated signaling
Activated PKR phosphorylates sphingosin kinase 1 (SPHK1) at S225 in the nucleus, priming it for nuclear export. This process is part of a feedback loop between PKR and SPHK1, activating pro-survival pathways in the cellular response to external stimuli (Qiao et al, 2020).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-9836617
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9836617