Reaction: p-PKR dimer phosphorylates PPP2R5A
- in pathway: PKR-mediated signaling
PPP2R5A, as a subunit of the phosphatase PP2A complex, can regulate the cellular location, substrate specification, and protein phosphatase function of PP2A. Protein kinase R (PKR, EIF2AK2) phosphorylates PPP2R5A at S28, which results in mitochondrial localization of PPP2R5A and activation of the PP2A holoenzyme. In contrast, silencing PKR significantly suppressed the activity of PP2A. PP2A activation supports apoptotic processes that likely include inactivation of BCL2 by dephosphorylation (Xu & Williams, 2000; Ruvolo et al, 2008; Yang et al, 2010; reviewed by Mao et al, 2018).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-9836664
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-9836664