Reaction: NUDT8 hydrolyzes CoA-SH to PPANT
- in pathway: Vitamin B5 (pantothenate) metabolism
Human NUDT8 protein has not been characterized experimentally. Its mitochondrial localization and ability to hydrolyze Coenzyme A (CoA-SH) to (R)-4'-phosphopantetheine (PPANT) and adenosine 3',5'-bisphosphate (PAP) are inferred from properties of Nudt8, its mouse ortholog (Kerr et al. 2019).
Reaction - small molecule participants:
PAP [mitochondrial matrix]
PPANT [mitochondrial matrix]
H+ [mitochondrial matrix]
CoA-SH [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-9837354
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Reaction input - small molecules:
coenzyme A(4-)
water
Reaction output - small molecules:
adenosine 3',5'-bismonophosphate(4-)
D-pantetheine 4'-phosphate(2-)
hydron
Reactome.org link: R-HSA-9837354