Reaction: PANK4 hydrolyzes PPANT to pantetheine
- in pathway: Vitamin B5 (pantothenate) metabolism
Cytosolic PANK4 hydrolyzes (R)-4'-phosphopantetheine (PPANT) to pantetheine (Huang et al. 2016). This reaction, coupled to the hydrolysis of CoA-SH mediated by NUDT enzymes, could play a role in rapidly reducing cellular CoA levels in response to changes in requirements for energy metabolism (Naquet et al. 2020).
Reaction - small molecule participants:
Pi [cytosol]
Pantetheine [cytosol]
H2O [cytosol]
PPANT [cytosol]
Reactome.org reaction link: R-HSA-9837419
======
Reaction input - small molecules:
water
D-pantetheine 4'-phosphate(2-)
Reaction output - small molecules:
hydrogenphosphate
pantetheine
Reactome.org link: R-HSA-9837419