Reaction: GM1 localizes to ILV membrane
- in pathway: Glycosphingolipid catabolism
As the late endosome becomes a lysosome, inward budding of the lysosomal membrane creates intralysosomal luminal vesicles (ILV) that carry lipids, including GM1, on their outside (reviewed by Sandhoff & Sandhoff, 2018).
Reaction - small molecule participants:
GM1 [multivesicular body, internal vesicle membrane]
GM1 [endosome membrane]
Reactome.org reaction link: R-HSA-9840579
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Reaction input - small molecules:
ganglioside GM1(1-)
Reaction output - small molecules:
alpha-N-acetylneuraminosyl-(2->3)-[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide(1-)
Reactome.org link: R-HSA-9840579