Reaction: ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5
Inositol-tetrakisphosphate 1-kinase (ITPK1) can phosphorylate inositol polyphosphates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl- channels.
Reaction - small molecule participants:
ADP [cytosol]
I(1,3,4,5,6)P5 [cytosol]
I(3,4,5,6)P4 [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-994137
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Reaction input - small molecules:
1D-myo-inositol 3,4,5,6-tetrakisphosphate(8-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
myo-inositol 1,3,4,5,6-pentakisphosphate(10-)
Reactome.org link: R-HSA-994137