Pathway: TAK1-dependent IKK and NF-kappa-B activation
Reactions in pathway: TAK1-dependent IKK and NF-kappa-B activation :
TAK1-dependent IKK and NF-kappa-B activation
NF-kappa-B is sequestered in the cytoplasm in a complex with inhibitor of NF-kappa-B (IkB). Almost all NF-kappa-B activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting in dissociation of NF-kappa-B from the complex. This allows translocation of NF-kappa-B to the nucleus where it regulates gene expression.
Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system.