Pathway: TRAF3-dependent IRF activation pathway
Reactions in pathway: TRAF3-dependent IRF activation pathway :
TRAF3-dependent IRF activation pathway
MAVS via its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the signaling complex. TRAF3 acts as a scaffold for the assembly of a signaling complex composed of IKK epsilon/TBK1, leading to the activation of transcription factors IRF3/IRF7.
Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system.