Reaction: D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate
- in pathway: 5-Phosphoribose 1-diphosphate biosynthesis
Cytosolic phosphoribosyl pyrophosphate synthetase 1 catalyzes the reaction of D-ribose 5-phosphate and dATP to form 5-phospho-alpha-D-ribose 1-diphosphate and 2'-deoxyadenosine 5'-monophosphate. While phosphoribosyl pyrophosphate synthetase 1 works well with either ATP or dATP as a substrate in vitro, the extent of the dATP reaction in vivo is unclear, as cellular dATP concentrations are normally very low (Fox and Kelley 1971).
Reaction - small molecule participants:
PRPP [cytosol]
2'-deoxyadenosine 5'-monophosphate [cytosol]
R5P [cytosol]
dATP [cytosol]
Reactome.org reaction link: R-HSA-111215
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Reaction input - small molecules:
D-ribofuranose 5-phosphate(2-)
dATP(4-)
Reaction output - small molecules:
5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
2'-deoxyadenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-111215