Reaction: IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
- in pathway: Purine ribonucleoside monophosphate biosynthesis
Two isoforms of adenylosuccinate synthetase, ADSS and ADSSL1, catalyze the reaction of IMP, aspartate, and GTP to form adenylosuccinate, GDP, and orthophosphate (Powell et al. 1992; Sun et al. 2005). ADSS is a homotetramer (unpublished crystallographic data - PDB 2V40) and ADSSL1 is inferred to be a tetramer likewise.
Reaction - small molecule participants:
Pi [cytosol]
GDP [cytosol]
H+ [cytosol]
ADS [cytosol]
GTP [cytosol]
L-Asp [cytosol]
IMP [cytosol]
Reactome.org reaction link: R-HSA-111524
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Reaction input - small molecules:
GTP(4-)
L-aspartate(1-)
IMP(2-)
Reaction output - small molecules:
hydrogenphosphate
GDP(3-)
hydron
N(6)-(1,2-dicarboxylatoethyl)-AMP(4-)
Reactome.org link: R-HSA-111524