Molecule: GTP(4-)

A nucleoside triphosphate(4-) obtained by global deprotonation of the triphosphate OH groups of GTP; major species present at pH 7.3.
Synonyms for GTP(4-) :
GTP
gtp
Molecular Formula: C10H12N5O14P3
Molecular wt: 519.14886 g/mole
Charge: -4
SMILES: Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O
InChIKey: XKMLYUALXHKNFT-UUOKFMHZSA-J
InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1
CHEBI:37565
Sample reactions for this molecule:
Adenylate Kinase 3 is a GTP-AMP phosphotransferase
GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
p115-RhoGEF activation of RHOA
Thrombin-activated PARs activate G12/13
Thrombin-activated PARs activate Gq
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)