Reaction: Oxidative demethylation of 3-meC damaged DNA by ALKBH2
- in pathway: ALKBH2 mediated reversal of alkylation damage
ALKBH2 catalyzes removal of the methyl group from 3-methylcytosine (3-meC) in a reaction that depends on oxygen, alpha-ketoglutarate and Fe2+. ALKBH2 thus directly reverses alkylation damage of DNA in the form of 3-meC, releasing formaldehyde (Duncan et al. 2002).
Reaction - small molecule participants:
CH2O [nucleoplasm]
CO2 [nucleoplasm]
SUCCA [nucleoplasm]
2OG [nucleoplasm]
O2 [nucleoplasm]
Reactome.org reaction link: R-HSA-112120
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
formaldehyde
carbon dioxide
succinate(2-)
Reactome.org link: R-HSA-112120