Molecule: 2-oxoglutarate(2-)

An oxo dicarboxylate obtained by deprotonation of both carboxy groups of 2-oxoglutaric acid.
Synonyms for 2-oxoglutarate(2-) :
2-ketoglutarate
2-oxoglutarate
2-oxopentanedioic acid, ion(2-)
alpha-ketoglutarate
Molecular Formula: C5H4O5
Molecular wt: 144.08226 g/mole
Charge: -2
SMILES: [O-]C(=O)CCC(=O)C([O-])=O
InChIKey: KPGXRSRHYNQIFN-UHFFFAOYSA-L
InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2
CHEBI:16810
Sample reactions for this molecule:
Oxidative demethylation of 1-meA damaged DNA by ALKBH2
Oxidative demethylation of 3-meC damaged DNA by ALKBH2
Oxidative dealkylation of 1-etA damaged DNA By ALKBH2
Oxidative demethylation of 1-meA damaged DNA By ALKBH3
Oxidative demethylation of 3-meC damaged DNA By ALKBH3
Oxidative dealkylation of 1-EtA damaged DNA by ABH3
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A)
Nuclear PHD1,3 hydroxylates proline residues on HIF3A
Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A