Reaction: Nuclear PHD1,3 hydroxylates proline residues on HIF3A
Proline hydroxylases PHD1 (EGLN2) and PHD3 (EGLN3) located in the nucleus (Metzen et al. 2003) hydroxylate HIF3A at proline-492 (Hirsila et al. 2003, Maynard et al. 2003). Note that proline-492 of the reference isoform is proline-490 in isoform 2, the protein cited by Maynard et al. 2003. The amount of hydroxylation occurring in the nucleus is controversial. Most hydroxylation is believed to occur in the cytosol.
Reaction - small molecule participants:
CO2 [nucleoplasm]
SUCCA [nucleoplasm]
2OG [nucleoplasm]
O2 [nucleoplasm]
Reactome.org reaction link: R-HSA-1234165
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
carbon dioxide
succinate(2-)
Reactome.org link: R-HSA-1234165