Reaction: NOX2 generates superoxide from oxygen
- in pathway: Detoxification of Reactive Oxygen Species
Macrophage NOX2 is a membrane complex that generates superoxide anions by reduction of oxygen with NADPH (Babior 1999, Dinauer et al. 1991).
Reaction - small molecule participants:
H+ [cytosol]
O2.- [cytosol]
NADP+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-1222376
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Reaction input - small molecules:
dioxygen
NADPH(4-)
Reaction output - small molecules:
hydron
superoxide
NADP(3-)
Reactome.org link: R-HSA-1222376