Molecule: NADPH(4-)

Tetraanion of NADPH arising from deprotonation of the diphosphate and phosphate OH groups; major species at pH 7.3.
Synonyms for NADPH(4-) :
NADPH
NADPH tetraanion
Molecular Formula: C21H26N7O17P3
Molecular wt: 741.38910 g/mole
Charge: -4
SMILES: NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](OP([O-])([O-])=O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
InChIKey: ACFIXJIJDZMPPO-NNYOXOHSSA-J
InChI=1S/C21H30N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35)/p-4/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
CHEBI:57783
Sample reactions for this molecule:
NOX2 generates superoxide from oxygen
Iron is reduced and separates from mycobactin
TrxB reactivates TrxA
PTHP is reduced to BH4 by sepiapterin reductase (SPR)
Salvage - BH2 is reduced to BH4 by DHFR
Uncoupled eNOS favours the formation of superoxide
Salvage - Sepiapterin is reduced to BH2
Salvage - Sepiapterin is reduced to BH2
CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO
FMO1:FAD oxidizes HTAU to TAU