Reaction: Iron is reduced and separates from mycobactin
- in pathway: Mtb iron assimilation by chelation
The IrtA transporter has a flavin reductase domain very much like Fre from E.coli that can probably act as ferrisiderophore reductase to relieve incoming loaded mycobactin from its Fe3+ by reducing it to Fe2+. Furthermore Rv2895c, which co-precipitates with IrtB and therefore is probably part of the transporter complex, has such a domain as well (Farhana et al. 2008).
Reaction - small molecule participants:
H+ [cytosol]
Fe2+ [cytosol]
NADP+ [cytosol]
Mycobactin [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-1222399
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Reaction input - small molecules:
NADPH(4-)
Reaction output - small molecules:
hydron
iron(2+)
NADP(3-)
desferrimycobactin T
Reactome.org link: R-HSA-1222399