Meta-Biol : Reactions : PTHP is reduced to BH4 by sepiapterin reductase (SPR)

Reaction: PTHP is reduced to BH4 by sepiapterin reductase (SPR)

- in pathway: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

Sepiapterin reductase (SPR) (Ichinose et al. 1991) reduces DHNTP to tetrahydrobiopterin (BH4).

Reaction - small molecule participants:

BH4 [cytosol]

NADP+ [cytosol]

PTHP [cytosol]

NADPH [cytosol]

Reactome.org reaction link: R-HSA-1475414

Reaction input - small molecules:

dyspropterin

NADPH(4-)

Reaction output - small molecules:

5,6,7,8-tetrahydrobiopterin

NADP(3-)

Reactome.org link: R-HSA-1475414