Reaction: Salvage - Sepiapterin is reduced to BH2
- in pathway: eNOS activation
In the first of two salvage steps to maintain BH4 levels in the cell, sepiapterin is taken up by the cell and reduced by sepiapterin reductase (SRP) to form BH2 (Sawabe et al. 2008).
Reaction - small molecule participants:
BH2 [cytosol]
NADP+ [cytosol]
H+ [cytosol]
sepiapterin [cytosol]
NADPH [cytosol]
BH2 [cytosol]
NADP+ [cytosol]
H+ [cytosol]
sepiapterin [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-1497869
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Reaction input - small molecules:
hydron
sepiapterin
NADPH(4-)
hydron
sepiapterin
NADPH(4-)
Reaction output - small molecules:
D-erythro-7,8-dihydrobiopterin
NADP(3-)
D-erythro-7,8-dihydrobiopterin
NADP(3-)
Reactome.org link: R-HSA-1497869