Reaction: Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants
EGFR L858R mutant was shown to directly phosphorylate CBL on tyrosine residue Y371. Other EGFR cancer mutants with phosphorylation of tyrosine Y1069 (i.e. Y1045 in the mature protein) are assumed to bind and phosphorylate CBL in a manner similar to the wild-type EGFR.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1225960
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-1225960