Reaction: Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A)
Proline hydroxylases PHD2 (EGLN1) and PHD3 (EGLN3) located in the cytosol (Metzen et al. 2003) hydroxylate EPAS1 (HIF2A) at proline-405 and proline-531 (Hirsila et al. 2003, Percy et al. 2008, Furlow et al. 2009). A portion of PHD3 (EGLN3) is also located in the nucleus (Rantanen et al. 2008).
Reaction - small molecule participants:
SUCCA [cytosol]
CO2 [cytosol]
2OG [cytosol]
O2 [cytosol]
Reactome.org reaction link: R-HSA-1234179
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Reaction input - small molecules:
2-oxoglutarate(2-)
dioxygen
Reaction output - small molecules:
succinate(2-)
carbon dioxide
Reactome.org link: R-HSA-1234179