Reaction: MTA is cleaved and phosphorylated
- in pathway: Methionine salvage pathway
MTA phosphorylase catalyzes the cleavage of adenine from S-methylthioadenosine (MTA) and subsequent phosphorylation of the product, yielding 5'-methylthio ribose-1-phosphate (Kamatani et al. 1981). The active form of the enzyme is a homotrimer (Della Ragione et al. 1985). Mutations in the gene are associated with a rare bone dysplasia and cancer syndrome, DMS-MFH (Camacho-Vanegas et al. 2012).
Reaction - small molecule participants:
MTRIBP [cytosol]
Ade [cytosol]
Pi [cytosol]
MTAD [cytosol]
Reactome.org reaction link: R-HSA-1237160
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Reaction input - small molecules:
hydrogenphosphate
5'-S-methyl-5'-thioadenosine
Reaction output - small molecules:
S-methyl-5-thio-alpha-D-ribose 1-phosphate(2-)
adenine
Reactome.org link: R-HSA-1237160