Reaction: BH2 binding can lead to eNOS uncoupling
- in pathway: eNOS activation
The oxidation product of BH4, 7,8-dihydrobiopterin (BH2), can compete with BH4 for binding to eNOS. This can lead to the uncoupling of eNOS and can result in the formation of reactive oxygen species (Vasquez-Vivar et al. 2002).
Reaction - small molecule participants:
BH4 [cytosol]
BH2 [cytosol]
BH4 [cytosol]
BH2 [cytosol]
Reactome.org reaction link: R-HSA-1497796
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Reaction input - small molecules:
D-erythro-7,8-dihydrobiopterin
D-erythro-7,8-dihydrobiopterin
Reaction output - small molecules:
5,6,7,8-tetrahydrobiopterin
5,6,7,8-tetrahydrobiopterin
Reactome.org link: R-HSA-1497796