Reaction: Peroxynitrite can oxidise BH4 to the BH3 radical
Peroxynitrite can oxidise BH4 to the BH3 radical, further reducing BH4 availability to couple eNOS activity and compounding the production of superoxide through uncoupled eNOS activity (Kuzkaya et al. 2003).
Reaction - small molecule participants:
BH3. [cytosol]
BH4 [cytosol]
Peroxynitrite [cytosol]
Reactome.org reaction link: R-HSA-1497866
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Reaction input - small molecules:
5,6,7,8-tetrahydrobiopterin
peroxynitrite
Reaction output - small molecules:
5,6,7,8-tetrahydrobiopterin radical cation
Reactome.org link: R-HSA-1497866