Reaction: Ferrous iron reduces the BH3 radical back to BH4
Heme iron from the oxygenase domain of eNOS can reduce the BH3 radical back to BH4, with itself being oxidised from the ferrous (Fe2+) back to the ferric (Fe3+) form (Berka et al. 2004).
Reaction - small molecule participants:
BH4 [cytosol]
Fe3+ [cytosol]
Fe2+ [cytosol]
BH3. [cytosol]
Reactome.org reaction link: R-HSA-1497883
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Reaction input - small molecules:
iron(2+)
5,6,7,8-tetrahydrobiopterin radical cation
Reaction output - small molecules:
5,6,7,8-tetrahydrobiopterin
iron(3+)
Reactome.org link: R-HSA-1497883