Reaction: ASAH2 hydrolyzes ceramide (plasma membrane)
- in pathway: Glycosphingolipid catabolism
Neutral ceramidase (ASAH2) is an enzyme localised to the plasma membrane that catalyses the hydrolysis of ceramide to sphingosine and free fatty acid (Hwang et al. 2005, Galadari et al. 2006).
Reaction - small molecule participants:
SPG [plasma membrane]
RCOO- [cytosol]
H2O [cytosol]
CERA [plasma membrane]
Reactome.org reaction link: R-HSA-1606583
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Reaction input - small molecules:
water
N-acylsphingoid
Reaction output - small molecules:
sphingoid base(1+)
fatty acid anion
Reactome.org link: R-HSA-1606583