Reaction: GTP loading by Rheb
- in pathway: MTOR signalling
Rheb is a GTP binding protein that exhibits GTPase activity. GDP is exchanged for GTP in the [Rheb:GDP] complex to form [Rheb:GTP], which binds and activates the mTORC1 complex. The GDP-bound form of Rheb also binds mTORC1 but does not lead to activation. This exchange may be catalysed by an as yet unidentified guanine exchange factor (GEF); the intrinsic exchange activity of Rheb may be sufficient in the absence of a GEF.
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-165195
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-165195