Reaction: Thiosulfate can transfer its sulfur atom to glutathione
- in pathway: Sulfide oxidation to sulfate
Thiosulfate is able to transfer its sulfur atom to glutathione, a reaction investigated in yeast (Chauncey & Westley 1983). Recombinant human thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (TSTD1 aka KAT1) (and its yeast equivalent RDL1) catalyse a predicted thiosulfate-dependent conversion of glutathione (GSH) to glutathione disulfide (GSSG) (Melideo et al. 2014).
Reaction - small molecule participants:
GSSG [mitochondrial matrix]
sulfite(2-) [mitochondrial matrix]
H2S [mitochondrial matrix]
S2O3(2-) [mitochondrial matrix]
H+ [mitochondrial matrix]
GSH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-1655879
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Reaction input - small molecules:
trioxidosulfanidosulfate(1-)
hydron
glutathione
Reaction output - small molecules:
glutathione disulfide(2-)
sulfite
hydrosulfide
Reactome.org link: R-HSA-1655879