Reaction: PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane
- in pathway: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A), beta (PIP4K2B) and gamma (PIP4K2C) homodimers and heterodimers (Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015) phosphorylate phosphatidylinositol 5-phosphate (PI5P) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).
The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013), PIP4K2B (Rameh et al. 1997, Clarke and Irvine 2013) and PIP4K2C (Clarke and Irvine 2013, Clarke et al. 2015).
The following lists the above proteins with their corresponding literature references: PIP4K2A (Rameh et al. 1997, Clarke et al. 2008, Clarke and Irvine 2013), PIP4K2B (Rameh et al. 1997, Clarke and Irvine 2013) and PIP4K2C (Clarke and Irvine 2013, Clarke et al. 2015).
Reaction - small molecule participants:
ADP [cytosol]
PI(4,5)P2 [plasma membrane]
PI5P [plasma membrane]
ATP [cytosol]
ADP [cytosol]
PI(4,5)P2 [plasma membrane]
PI5P [plasma membrane]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1675776
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
ATP(4-)
1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
ADP(3-)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reactome.org link: R-HSA-1675776