Molecule: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)

The pentaanion of a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Synonyms for 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) :
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
Molecular Formula: C11H14O19P3R2
Molecular wt: 543.139 g/mole
Charge: -5
SMILES: O[C@@H]1[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@@H](O)[C@@H]1OP([O-])(=O)OC[C@@H](COC([*])=O)OC([*])=O
InChIKey:
CHEBI:58456
Sample reactions for this molecule:
PI3K-containing complexes phosphorylate PIP2 to PIP3
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
Synthesis of PIP3 from PIP2 by PI3K