Reaction: PIP2 hydrolysis
- in pathway: PLC beta mediated events
The phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. One type, PLC-beta1, hydrolyzes phosphatidylinositol bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes intracellular calcium stores while DAG activates protein kinase C isoforms which are involved in regulatory functions.
Reaction - small molecule participants:
I(1,4,5)P3 [cytosol]
DAGs [plasma membrane]
H2O [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-111879
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Reaction input - small molecules:
water
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1D-myo-inositol 1,4,5-trisphosphate(6-)
diglyceride
Reactome.org link: R-HSA-111879