Reaction: PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane
- in pathway: Synthesis of PIPs at the Golgi membrane
At the Golgi membrane, phosphatidylinositol 4-phosphate (PI4P) inositol polyphosphate 5-phosphatase OCRL-1 (OCRL) (Choudhury et al. 2009, Suchy et al. 1995, Zhang et al. 1995) and 72 kDa inositol polyphosphate 5-phosphatase (INPP5E) (Bilas et al. 2009) dephosphorylate phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) to form phosphatidylinositol 4-phosphate (PI4P). INPP5E is located in the Golgi membrane, mediated by its N-terminal proline-rich domain (Kong et al. 2000).
Reaction - small molecule participants:
Pi [cytosol]
PI4P [Golgi membrane]
PI(4,5)P2 [Golgi membrane]
H2O [cytosol]
Reactome.org reaction link: R-HSA-1675824
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
water
Reaction output - small molecules:
hydrogenphosphate
1-phosphatidyl-1D-myo-inositol 4-phosphate
Reactome.org link: R-HSA-1675824