Meta-Biol

• Pathways

LGP2 acts as a natural negative regulator of dsRNA signaling. Several mechanisms may account for the LGP2 inhibitory effects. As a homolog of RIG-I, one attractive model is that LGP2 can sequester RNA ligands from recognition by RIG-I/MDA5. LGP2 has also been demonstrated to associate with RIG-I to inhibit its auto-oligomerizaton via the LGP2 C-terminal region comparable to the RIG-I repressor domain. In this model, dimerization of RIG-I by viral RNA, proposed to be an active form of RIG-I, is replaced by a RIG-I:LGP2 hetero-oligomer.