Reaction: IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel

- in pathway: Ca2+ pathway
The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.
Reaction - small molecule participants:
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 [cytosol]
Reactome.org reaction link: R-HSA-169680

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Reaction input - small molecules:
1D-myo-inositol 1,4,5-trisphosphate(6-)
ChEBI:203600
1D-myo-inositol 1,4,5-trisphosphate(6-)
ChEBI:203600
1D-myo-inositol 1,4,5-trisphosphate(6-)
ChEBI:203600
1D-myo-inositol 1,4,5-trisphosphate(6-)
ChEBI:203600
1D-myo-inositol 1,4,5-trisphosphate(6-)
ChEBI:203600
1D-myo-inositol 1,4,5-trisphosphate(6-)
ChEBI:203600
1D-myo-inositol 1,4,5-trisphosphate(6-)
ChEBI:203600
1D-myo-inositol 1,4,5-trisphosphate(6-)
ChEBI:203600
1D-myo-inositol 1,4,5-trisphosphate(6-)
ChEBI:203600
1D-myo-inositol 1,4,5-trisphosphate(6-)
ChEBI:203600
Reaction output - small molecules:
Reactome.org link: R-HSA-169680