Reaction: AHCY:NAD+ tetramer hydrolyses AdoHcy
- in pathway: Sulfur amino acid metabolism
Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, cytosolic protein that regulates all adenosylmethionine-(AdoMet) dependent transmethylations by hydrolysing the feedback inhibitor adenosylhomocysteine (AdoHcy) to homocysteine (HCYS) and adenosine (Ade-Rib) (Turner et al. 1998, Yang et al. 2003).
Reaction - small molecule participants:
Ade-Rib [cytosol]
HCYS [cytosol]
H2O [cytosol]
AdoHcy [cytosol]
Ade-Rib [cytosol]
HCYS [cytosol]
H2O [cytosol]
AdoHcy [cytosol]
Reactome.org reaction link: R-HSA-174401
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Reaction input - small molecules:
water
S-adenosyl-L-homocysteine zwitterion
water
S-adenosyl-L-homocysteine zwitterion
Reaction output - small molecules:
adenosine
homocysteine zwitterion
adenosine
homocysteine zwitterion
Reactome.org link: R-HSA-174401