Reaction: The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere
- in pathway: Telomere C-strand synthesis initiation
The complementary C-strand at telomeres is synthesized by the polymerase alpha:primase complex using conventional RNA priming (Nakamura et al. 2005, Dai et al. 2010). This process is regulated by the CST complex (Dai et al. 2010, Feng et al. 2017, Feng et al. 2018) and CDK1 (Dai et al. 2010, Dai et al. 2012).
Reaction - small molecule participants:
dTTP [nucleoplasm]
dCTP [nucleoplasm]
dGTP [nucleoplasm]
dATP [nucleoplasm]
Reactome.org reaction link: R-HSA-174427
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Reaction input - small molecules:
dTTP(4-)
dCTP(4-)
dGTP(4-)
dATP(4-)
Reaction output - small molecules:
Reactome.org link: R-HSA-174427