Reaction: BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3.
- in pathway: Signaling by cytosolic FGFR1 fusion mutants
Once recruited to the activated BCR-FGFR1 fusion PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling (Roumiantsev, 2004; Demiroglu, 2001).
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
ADP [cytosol]
ATP [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-1839107
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
ADP(3-)
Reactome.org link: R-HSA-1839107