Reaction: I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
- in pathway: Synthesis of IP3 and IP4 in the cytosol
Inositol-trisphosphate 3-kinase A (ITPKA), B (ITPKB), and C (ITPKC) phosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) (Dewaste et al. 2003).
Reaction - small molecule participants:
ADP [cytosol]
I(1,3,4,5)P4 [cytosol]
ATP [cytosol]
I(1,4,5)P3 [cytosol]
Reactome.org reaction link: R-HSA-1855153
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Reaction input - small molecules:
ATP(4-)
1D-myo-inositol 1,4,5-trisphosphate(6-)
Reaction output - small molecules:
ADP(3-)
1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
Reactome.org link: R-HSA-1855153