Reaction: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
- in pathway: Synthesis of IP2, IP, and Ins in the cytosol
A group of inositol phosphatases dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate (I(1,4)P2). The group of inositol phosphatases involved are: inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J), and synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1).
The following lists the above proteins with their corresponding literature references: OCRL (Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004).
The following lists the above proteins with their corresponding literature references: OCRL (Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004).
Reaction - small molecule participants:
Pi [cytosol]
I(1,4)P2 [cytosol]
H2O [cytosol]
I(1,4,5)P3 [cytosol]
Reactome.org reaction link: R-HSA-1855174
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Reaction input - small molecules:
water
1D-myo-inositol 1,4,5-trisphosphate(6-)
Reaction output - small molecules:
hydrogenphosphate
1D-myo-inositol 1,4-bisphosphate
Reactome.org link: R-HSA-1855174