Reaction: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen
- in pathway: Synthesis of IPs in the ER lumen
In the endoplasmic reticulum (ER) lumen, multiple inositol polyphosphate phosphatase 1 (MINPP1) dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,4,5-trisphosphate (I(1,4,5)P3) (Caffrey et al. 1999, Chi et al. 1999).
Reaction - small molecule participants:
Pi [endoplasmic reticulum lumen]
I(1,4,5)P3 [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
I(1,3,4,5)P4 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-1855200
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Reaction input - small molecules:
water
1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
Reaction output - small molecules:
hydrogenphosphate
1D-myo-inositol 1,4,5-trisphosphate(6-)
Reactome.org link: R-HSA-1855200