Reaction: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol

- in pathway: Synthesis of IP3 and IP4 in the cytosol
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase aka phosphatase and tensin homolog (PTEN) dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,4,5-trisphosphate (I(1,4,5)P3) (Maehama & Dixon 1998, Han et al. 2000).
Reaction - small molecule participants:
Pi [cytosol]
I(1,4,5)P3 [cytosol]
H2O [cytosol]
I(1,3,4,5)P4 [cytosol]
Reactome.org reaction link: R-HSA-1855205

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Reaction input - small molecules:
water
ChEBI:15377
1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
ChEBI:57895
Reaction output - small molecules:
hydrogenphosphate
ChEBI:43474
1D-myo-inositol 1,4,5-trisphosphate(6-)
ChEBI:203600
Reactome.org link: R-HSA-1855205