Reaction: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
- in pathway: Synthesis of IP2, IP, and Ins in the cytosol
Type I inositol-1,4,5-trisphosphate 5-phosphatase (INPP5A) and the Type II phosphatase (INPP5B) are isoprenylated to the plasma membrane and act as a lipid anchor. Here they dephosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,4-bisphosphate I(1,4)P2. ).
The following lists the above proteins with their corresponding literature references: INPP5A (Laxminarayan et al. 1994); INPP5B (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004).
The following lists the above proteins with their corresponding literature references: INPP5A (Laxminarayan et al. 1994); INPP5B (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004).
Reaction - small molecule participants:
Pi [cytosol]
I(1,4)P2 [cytosol]
H2O [cytosol]
I(1,4,5)P3 [cytosol]
Reactome.org reaction link: R-HSA-1855222
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Reaction input - small molecules:
water
1D-myo-inositol 1,4,5-trisphosphate(6-)
Reaction output - small molecules:
hydrogenphosphate
1D-myo-inositol 1,4-bisphosphate
Reactome.org link: R-HSA-1855222