Reaction: I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus
- in pathway: Synthesis of IPs in the nucleus
In the nucleus, inositol polyphosphate multikinase (IPMK) phosphorylates inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) (Nalaskowski et al. 2002, Chang et al. 2002, Chang & Majerus 2006).
Reaction - small molecule participants:
ADP [nucleoplasm]
I(1,3,4,5)P4 [nucleoplasm]
ATP [nucleoplasm]
I(1,4,5)P3 [nucleoplasm]
Reactome.org reaction link: R-HSA-1855233
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Reaction input - small molecules:
ATP(4-)
1D-myo-inositol 1,4,5-trisphosphate(6-)
Reaction output - small molecules:
ADP(3-)
1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
Reactome.org link: R-HSA-1855233