Reaction: PI3K catalyses the phosphorylation of PIP2 to PIP3
- in pathway: Downstream signal transduction
The preferred substrate of PI3K is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] (PIP2), which is phosphorylated to the trisphosphate [PI(3,4,5)P3] (PIP3). PI3-kinase and its products have been found to be of importance in PDGF-stimulated actin reorganization, and directed cell movement, as well as in the stimulation of cell growth and inhibition of apoptosis.
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
ADP [cytosol]
ATP [cytosol]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-186800
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Reaction input - small molecules:
ATP(4-)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
ADP(3-)
Reactome.org link: R-HSA-186800