Reaction: SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
- in pathway: Downstream signal transduction
SOS is the guanine nucleotide exchange factor (GEF) for RAS. SOS activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-186834
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-186834