Reaction: BLVRA:Zn2+, BLVRB reduce BV to BIL
- in pathway: Heme degradation
Bilirubin (BIL) is the breakdown product of heme, causing death if allowed to accumulate in the blood. It is highly lipophilic and requires conjugation to become more water soluble to aid excretion. BIL is formed from the reduction of biliverdin (BV) by bilverdin reductases BLVRA and BLVRB (Cunningham et al. 2000, Fu et al. 2012, O'Brien et al. 2015).
Reaction - small molecule participants:
BIL [cytosol]
NADP+ [cytosol]
BV [cytosol]
NADPH [cytosol]
BIL [cytosol]
NADP+ [cytosol]
BV [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-189384
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Reaction input - small molecules:
biliverdin(2-)
NADPH(4-)
biliverdin(2-)
NADPH(4-)
Reaction output - small molecules:
bilirubin(2-)
NADP(3-)
bilirubin(2-)
NADP(3-)
Reactome.org link: R-HSA-189384